|
KMID : 1134820130420030384
|
|
Journal of the Korean Society of Food Science and Nutrition
2013 Volume.42 No. 3 p.384 ~ p.388
|
|
|
Anti-Inflammatory Effects of Extracts from Caesalpinia sappan L. on Skin Inflammation
|
|
Eum Won-Sik
Lee Kwang-Jae
Kim Dae-Won
Lim Soon-Sung
Kang Il-Jun
Park Jin-Seu
Choi Soo-Young
|
|
|
Abstract
|
|
|
|
This study investigated the anti-inflammatory effects of extracts from Caesalpinia sappan L. (CSL) on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema in mice. Skin inflammation was detected by immunohistochemistry and the protein and mRNA expression levels of cyclooxygenase-2 (COX-2) and cytokines (IL-6, IL-1β and TNF-α) detected by Western blotting and RT-PCR. The activation of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) were analyzed by Western blotting. CSL extracts markedly inhibited the TPA-induced expression of COX-2 and pro-inflammatory cytokines. Also, CSL extracts significantly reduced the activation of NF-κB and MAPK. These results suggest that CSL extracts may serve as therapeutic agents against skin diseases related to inflammation.
|
|
|
KEYWORD
|
|
|
inflammation, TPA, Caesalpinia sappan L., NF-κB, MAPK
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|